Neurobehavioral Aspects of Developmental Toxicity Testing
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چکیده
منابع مشابه
Neurobehavioral aspects of developmental toxicity testing.
Tests for detection of neurobehavioral changes in the offspring have been a regulatory requirement in developmental toxicity testing of drugs for almost 20 years. Keeping their purpose of hazard identification and risk assessment for humans in mind, investigators and agency reviewers have become deeply ingrained with some stereotyped behaviors with respect to such relevant issues as choice of a...
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The assessment of behavioral changes produced by prenatal or early postnatal exposure to potentially noxious agents requires both the designing of ad hoc tests and the adaptation of tests for adult animals to the characteristics of successive developmental stages. The experience in designing tests is still more limited than in the adaptation of tests, but several tests have already proven their...
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Reproductive toxicity testing is one of the most complex, expensive and labor intensive fields of toxicology (Leist et al. drastically demonstrate the fundamental importance of reliable developmental toxicity tests for human safety (van Recently, human embryonic stem cell based in vitro test systems have been established that recapitulate critical periods of human early development (Krug et al....
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Correspondence address: Assoc Prof. Eduard Ujházy, PhD. Department of Reproductive Toxicology, Institute of Experimental Pharmacology, Slovak Academy of Sciences, Dúbravská cesta 9, 841 04 Bratislava, Slovakia, e-mail: [email protected] Studies of individual development and its possible deterioration have been the concern since the 19th century, when Etienne Geoffroy de Saint-Hilaire (1772...
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Martin Farlow MD, editor. Dr. Farlow of Indiana University School of Medicine received research grant support from BristolMyersSquibb, Danone, Eisai, Elan, Eli Lilly, Genentech, Novartis, OctaPharma, Pfizer, Roche, Sanofi-Aventis, and Sonexa; honorariums from Eisai, Forest Laboratories, Pfizer, and Novartis for speaking engagements; and fees from Accera, Alltech, Astellas, Baxter Healthcare, Ba...
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ژورنال
عنوان ژورنال: Environmental Health Perspectives
سال: 1996
ISSN: 0091-6765
DOI: 10.2307/3432662